Does CBD Oil Work for Migraines?

Does CBD Oil Work for Migraines?

CBD Oil for Migraines

Toward the end associated with the century that is 19th cannabis had been a main-stream treatment for preventing and relieving migraines along with other kinds of headaches. Numerous physicians advocated becausage of its use through to the 1940s, when cannabis had been taken off the pharmacopeias that are official to its “high prospect of abuse” 1+, 2.

The legalization that is recent of marijuana and CBD oil in many nations worldwide revived the almost-forgotten usage of cannabis for headaches. But, it is essential to notice that the only real medical utilization of CBD authorized because of the Food And Drug Administration would be to reduce seizures in 2 forms of epilepsy 3.

Migraines as well as other forms of headaches are, after joint disease, the painful conditions many commonly enhanced with CBD oil. In a study on 1500 medical CBD users, roughly one away from six reported struggling with headaches 4.

30% of medical cannabis users reported doing so to ease migraines as well as other headaches in 2 studies on almost 2500 individuals. Nonetheless, the absolute most popular variety among them had been “OG Shark,” a THC-rich hybrid strain with a low CBD content 5, 6.

This renders us using the concern: does CBD oil alone relieve migraines as well as other kinds of headaches or should you just take THC-containing cannabis strains to obtain the pain-relieving advantages? Let’s look in the technology of CBD first to obtain the answers.

How Exactly Does It Work?

No matter what the type, headaches include an overactivation of nerves attached to arteries within the mind (trigeminovascular system) 2, 7+.

Released vessel-widening proteins (CGRP and substance P) and messengers (NO) increase blood circulation, which stimulates discomfort receptors on nerve cells into the head and neck. Headaches are really a direct outcome of the stimulation, while medications for headaches frequently block these receptors 2, 7+.

Boosts Normal Cannabinoids

The endocannabinoid system is consists of two receptors: CB1 and CB2. Both THC from cannabis and also the cannabinoids obviously made by the human anatomy, such as for instance anandamide, relieve pain by activating these receptors 8, 10, 11.

CBD is significantly diffent: it blocks in place of activates these receptors. Nonetheless, it prevents anandamide from being divided. Interestingly, a concept from the very early twenty-first century linked migraines (along with other chronic discomfort conditions) with low anandamide levels 12, 10, 13, 14, 15.

In reality, further studies revealed that individuals – and specially women – with migraines frequently have less anandamide into the fluid that is spinal platelets 16, 17, 18.

The exact same ended up being real in people who have headaches from overusing painkillers; after they withdrew through the medications, that they had less breakdown that is anandamide pain 19, 20.

People who have chronic headaches have actually reduced anandamide levels and higher CGRP and NO production. CB1 activation by anandamide and artificial cannabinoids blocks the production of CGRP with no, which prevents (trigeminovascular) neurological overstimulation and headaches 21, 22, 23, 24, 16.

Activates Serotonin Receptors

As hinted above, anandamide reduces migraines by activating CB1. In rats, blockers for the serotonin receptor 5HT(1B/1D) prevented anandamide from activating CB1. This receptor features a role that is well-known relieving headaches and its own activators (called triptans) are traditional drugs for migraines 25, 26, 27.

CBD may reduce neurological discomfort by activating another serotonin receptor (5HT1A), which will be based in the back as opposed to when you look at the mind 28|relative head28, 29, 30, 31.

Activates the TRPV1 Receptor

CBD and anandamide can bind to a receptor involved with inflammatory pain (TRPV1). Its activation causes the production of CGRP, which increases blood circulation to your nerves that are trigeminal. This shows that CBD might cause headaches 14, 32, 33, 34, 35.

Nevertheless, repeated TRPV1 activation reduces sensitivity to discomfort. Certainly, a nose spray because of the chili pepper compound capsaicin – which also activates this receptor – relieved migraines in a little test on 8 individuals 14, 36+.

Blocks Glutamate

Alterations in vision, flexibility, or speech called aura typically precede migraine assaults. These harbingers that are migraine brought on by glutamate cbd overactivation within the mind. Anandamide, THC, and artificial cannabinoids block glutamate receptors, suggesting they assist in preventing auras 2, 37, 38, 39, 40.

Reduces Inflammation and Autoimmunity

Autoimmune conditions may trigger migraines as well as other forms of headaches when they result infection regarding the blood vessels when you look at the brain. Certainly, conditions such as for instance numerous sclerosis, lupus, Sjцgren syndrome, and syndrome that is antiphospholipid associated with regular headaches 41.

CBD may relieve headaches in individuals with these conditions through its strong activity that is anti-inflammatory. It decreases the manufacturing of pro-inflammatory messengers (such as for instance IL-1beta, IL-6, TNF-alpha, IFN-gamma. NO, and prostaglandins) while enhancing the amounts of the cytokines that are anti-inflammatory and IL-10 43, 44, 45, 46, 47.

Instead, it would likely avoid the the signs of autoimmune disorders by curbing the resistant reaction. By way of example, CBD prevented T cells from multiplying and building up within the minds of mice with multiple sclerosis – while reducing the autoimmune-linked Th17 reaction 48, 49.

When Does It Work?


In a study on over 100 people who have migraines utilizing medicinal cannabis (with both CBD and THC), 85% reported paid down pain and frequency 50 that is migraine.

A preparation with more CBD than THC prevented attacks as effectively as a migraine drug (amitriptyline) in a clinical trial on 79 people with chronic migraines. a dose that is additional the assaults paid off pain. Likewise, 3 hefty cannabis cigarette smokers began having migraines once they stopped; one got rest from smoking once once again 51.

THC may account fully for a part that is great of impacts. THC alone prevented migraine assaults and reduced pain in rats. In comparison, its overuse might have the reverse effect: high doses increased sensitivity to repeated neurological stimulation – a suspected migraine trigger 53, 54.

Taken together, there isn’t any evidence that CBD oil improves migraines. Studies in rats even claim that THC in the place of CBD will be the cannabinoid responsible for the pain sensation relief seen in individuals utilizing cannabis preparations for migraines.

Other Types of Headaches

In research on over 100 individuals with cluster headaches, 45% utilized cannabis but just 25% skilled relief while 22percent felt even worse 55.

In one single report, leisure marijuana and synthetic THC (dronabinol) enhanced frequent cluster headaches in an adolescent. The power had been most likely from THC, not CBD 56.

In an endeavor on 13 people who have headaches from overusing painkillers, cannabis preparations pain that is reduced. Nonetheless, the planning utilizing the THC content that is highest (oil) was more efficient. In accordance with this, an artificial THC substance (nabilone) reduced discomfort additionally the significance of painkillers a lot better than ibuprofen in another trial on 26 individuals 57, 58.

When you look at the term that is short THC as well as other CB1 activators additionally relieved headaches from painkillers in rats. But, their repeated use increased sensitiveness to discomfort meaning that is might trigger migraines 54.

Both medical cannabis and an artificial THC substance (dronabinol) relieved headaches in 2 ladies with a high force into the brain (pseudotumor cerebri) 59+, 60.

A couple of clinical and animal studies recommend that CBD is perhaps inadequate for cluster headaches and headaches from overusing painkillers. THC appears to be the only cannabinoid providing some pain alleviation, nevertheless the proof remains restricted.


There are not any clinical trials testing CBD alone for headaches. Many of them utilized cannabis preparations with adjustable quantities of THC and CBD.

Many people with migraines prefer THC-rich cannabis strains. Plus, synthetic THC analogs had been also effective. This shows that migraine relief requires direct activation that is CB1 only THC will probably achieve. Having said that, CBD may help by boosting slightly anandamide levels.

CBD Oil Dosage for Migraines


Because CBD is certainly not approved for migraines or just about any other forms of headaches, there is absolutely no dose that is official. There’s no confirmed dosage either because CBD alone hasn’t been tested in clinical studies. The study that is only a item greater in CBD than in THC (9% vs 0.4%) used a dosage of 200 mg (supplying 18 mg CBD) a day. Nonetheless, we can’t rule the contribution out of the THC content to your results 51+.

We could furthermore estimate dose on the basis of the recommendations from manufacturers and users.

One maker of the commercial oil specifically formulated for migraines recommends 1 mL (providing 33 mg CBD) per day.

Normal wellness blogs and users choose reduced doses (15-25 mg/day). They often suggest beginning with a low dose and increasing it until observing pain-relieving effects. It’s important to achieve this slowly, since high doses may trigger migraines while increasing hassle intensity 61.

Whatever the case, don’t try CBD oil or some other therapies that are unproven migraines and headaches without consulting the doctor ahead of time. Consult with your medical professional if CBD oil can help available for you and what dose and form that is delivery be better for your needs.

Just how to make use of

CBD oil is available in various forms. Your kind of option may be determined by your style of frustration 62+:

  • Vaping, mouth sprays, and oil tinctures are consumed quickly and supply pain relief that is temporary. They might are more effective for cyclically-arising headaches such as for example group headaches.
  • Capsules, edibles, and teas discharge the CBD more slowly however their effects keep going longer. They may be better for conditions with constant discomfort such as for example headaches from overusing painkillers.

Although migraine discomfort is certainly not constant, slow-release CBD types could be more efficient (predicated on CBD’s connection aided by the TRPV1 receptor). Acute CBD doses may trigger migraine assaults while repeated doses decrease pain perception.

Anecdotal proof from internet forums advises taking cannabis that are medicinal soon after just starting to sense the onset of a migraine or cluster hassle attack 61.

Most readily useful CBD Oil for Migraines

As well as selecting a CBD oil modified to your allowance (you might want to determine the purchase price per mL or mg to compare brands that are different, it’s also wise to assess the product quality. Read here on how to pick the CBD oil that is best.


The opinions expressed in this part are entirely those of CBD oil users whom may or might not have medical or systematic training. Their reviews usually do not express the views of SelfHacked. SelfHacked will not endorse any product that is specific solution, or therapy.

Try not to consider individual experiences as medical advice. Never ever wait or disregard looking for expert medical advice from your medical professional or any other qualified medical providers as a result of one thing you’ve got continue reading SelfHacked. We realize that reading specific, real-life experiences may be a helpful resource, however it is never ever a replacement for professional medical advice, diagnosis, or therapy from a healthcare provider that is qualified.

Probably the most typical hassle type among CBD oil users had been migraine, followed closely by tension hassle, and frustration from painkiller overuse or conditions such as for instance fibromyalgia. Many of them were pleased and reported pain relief that is good. In several instances, the users reported some advantages such as for example enhancing rest quality and curbing anxiety.

Some users complained that the oil didn’t work that it made them drowsy and fatigued for them or. CBD oil even caused headaches in a few individuals using it at high doses.


Many people with migraines utilize THC-rich cannabis strains, although some prefer CBD oil. No studies that are clinical yet tested CBD oil alone for headaches or migraines.

Animal studies reveal that CBD oil may alleviate headaches – but just into the long haul and not likely in addition to THC.

Sudden surges in CBD, such as for example from vaping, might cause migraines. But taken long-term, CBD may decrease pain perception and stop auras that are migraine. It primarily functions by boosting your cannabinoid that is natural bliss.

CBD oil are often a choice for those who have migraines and headaches from autoimmune diseases like lupus and sclerosis that is multiple. In these instances, it probably helps by reducing mind irritation and suppressing autoimmunity.

Go with capsules or edibles and simply just take them every day for the very best results.

Vendors offer CBD oil on Amazon, but the majority of of them usually do not meet quality requirements. Some don’t even specify the CBD content within their products, while other people sell hemp oil with small or no CBD. These types of vendors are never to be trusted.

We recommend the following brand, which specifies quality procedures and CBD content within their items:

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